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Saventaro -
30 caps, (Enzymatic Therapy)
Saventaro
Enhances natural immunity
Benefits- Supports healthy B- and T-cell development.
- Supports joint health by modifying the immune system.
- Patented, clinically studied, and guaranteed to benefit the natural and acquired immune systems and support your body's own anti-inflammatory responses.
Key Features- Made from verified POA Cat's Claw that affects your cellular immune system and supports the body's ability to produce the optimal level of immune activity.
- Standardized to be free of harmful levels of of tetracyclic oxindole alkaloids (TOAs) commonly found in traditional Cat’s Claw.
Saventaro contains a uniquely standardized extract of Uncaria tomentosa from the root of the plant. Saventaro is analyzed and lab certified by high performance liquid chromatography (HPLC) to be free from harmful levels of tetracyclic oxindole alkaloids (TOAs).
The powerful plants used in Saventaro come to us through the generosity of the Asháninka people of Peru. In return, they receive financial support for education, medical care, and the vital protection of their rainforest lands.
SUGGESTED USAGE
One UltraCap three times daily for the first 10 days, and one UltraCap daily thereafter.
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Retail Price: $17.50
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Saventaro -
30 caps, (Enzymatic Therapy)
POA Cat's Claw (Uncaria tomentosa) (pentacyclic chemotype) 20 mg
(Saventaro brand) Root Extract standardized to contain 1.3% pentacyclic oxindole alkaloids (POAs) and to be free of tetracyclic oxindole alkaloids (TOAs)
Other Ingredients
cellulose, vegetable polysaccharide capsule, calcium carbonate, magnesium stearate, and silicon dioxide.
Contains No
sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, preservatives or ingredients of animal origin. This product contains natural ingredients; color variations are normal.
Notes
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.
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Saventaro -
30 caps, (Enzymatic Therapy)
Editor's rating: 7 out of 10
User's rating:  0%  0%
USER'S OPINION
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Saventaro -
30 caps, (Enzymatic Therapy)
How It Works
Saventaro is a unique extract of Uncaria tomentosa that both enhances natural immunity and modifies the acquired immune system. To the Ashaninka Indians in the Central Peruvian rain forest where Saventaro is harvested, the pentacyclic alkaloid-chemotype of U. tomentosa is a beneficial plant that they call saventaro (saveshi=plant, antearo=potent).
Saventaro is made from the root extract of U. tomentosa, which contains significantly higher total alkaloids than the bark. In addition, the root is the only part of the plant that contains an important pentacyclic oxindole alkaloid, isomitraphylline. The majority of research by IMMODAL on U. tomentosa has been done using standardized extracts, pure alkaloids, or standardized mixtures of alkaloids.
In nature, U. tomentosa occurs in two distinct chemotypes (chemical composition): one containing pentacyclic oxindole alkaloids (POAs), and another containing tetracyclic oxindole alkaloids (TOAs). While chemotypes of a particular species may be visually indistinguishable, the chemical constituents and therefore the biological activity differ greatly. This makes it difficult and time consuming to ensure that the correct plant chemotype is harvested. IMMODAL has developed a proprietary process to determine, at harvesting time, if U. tomentosa is the POA or TOA chemotype. This process, which later includes HPLC, guarantees that Saventaro is TOA-free.
Saventaro is guaranteed to contain only POAs, which possess immuno-modulating properties. In contrast, TOAs can affect the central nervous system, inhibit platelet aggregation, weaken the strength of heart contractions and adversely affect heart rate, lower blood pressure, and, in larger doses, paralyze respiration and produce irregular muscle contractions. The beneficial effects of POAs are antagonized/inhibited by TOAs if the two types are mixed.
The Immune System
Immunity is the general ability of an individual to resist a pathogen, which is a foreign substance that causes infection, and is composed of two responses: natural (nonspecific) immunity, and acquired (specific) immunity. Both natural and acquired immunity rely on the activity of white blood cells (leukocytes). However, natural immunity is mediated primarily by granulocytes (white blood cells that are typically phagocytic cells), while acquired immune responses are mediated by lymphocytes (white blood cells classified as either B or T lymphocytes).
The natural immune response is the first line of defense that offers immediate protection against a variety of foreign substances. This can include skin and mucous membrane integrity, inflammation, fever, and an initial cellular response. The phagocytic cells (eg, macrophages and granulocytes) of the natural immune system play two key roles: they present antigens to the acquired immune system, and they directly engulf and destroy pathogens.
Acquired immunity occurs throughout the lifetime of an individual as an adaptive response to infection by a pathogen. This specific immunity involves a cell mediated response and a humoral immune response. The cell mediated response, the second line of immune defense that follows natural immunity, relies on killer T cells to attack pathogens directly. Humoral immunity, the third and strongest line of immune defense, involves the production of antibodies (specific molecules of the humoral immune response that bind to and neutralize pathogens or prepare them for uptake and destruction by phagocytes) by B lymphocytes in response to a particular antigen (an invading substance capable of eliciting an immune response, particularly the generation of antibodies).
The acquired immune response is considered specific because both the B and T lymphocytes bear very diverse receptors on their surfaces, each of which is specific for a particular antigen. When presented with an antigen, B lymphocytes differentiate into memory B cells (B cells that can remember the antigen and quickly respond to identical antigens in subsequent attacks) and plasma cells (B cells that release antibodies to help macrophages digest pathogens). The other type of lymphocyte, T cells, are further differentiated into helper T cells (CD4 or T4) and cytotoxic/killer T cells (CD8 or T8). Helper T cells help activate other cells (eg, B cells and macrophages) in the immune response, while the cytotoxic T cells directly kill foreign cells.
Stimulation by a pathogen induces an immature lymphocyte to become an active lymphoblast. In order for the immune system to generate sufficient and specific lymphocytes (B and T) to respond to these antigens, the lymphoblast proliferates and differentiates into specific lymphoycte cells able to secrete antibodies, in the case of B cells, or in the case of T cells, to destroy infected cells or activate other components of the immune system. These more differentiated (cells that are more mature and less aggressive than their poorly differentiated counterparts) lymphocytes then migrate through the endothelial cells at the sites of infection.
Saventaro's Effect on the Natural Immune System
POAs from the root of U. tomentosa have been shown to enhance the natural immune system. More specifically, certain POAs (isopteropodine showing the strongest activity) directly increased the rate of phagocytosis (the process of engulfing and destroying foreign particles) mediated by granulocytes in vitro and by cells of the reticulo endothelial system in a mouse-model. Extracts of U. tomentosa have also been shown to increase interleukin (important cytokines made by white blood cells) production by macrophages in a dose-dependent manner.
Saventaro's Effect on the Acquired Immune System
POAs from the root of U. tomentosa exert their effects on the acquired immune system through a novel immune modulating factor. This factor is referred to in the scientific literature as "endothelial lymphocyte-proliferation regulating factor". This factor causes an increase in the proliferation of resting and weakly activated lymphocytes (B, T4, and T8), while at the same time, it inhibits the proliferation of highly activated lymphoblasts (B and T). The discovery of the action of this factor by IMMODAL is the subject of a pending patent.
Research has shown that levels of resting and weakly activated B and T lymphocytes in vitro are significantly increased by the addition of POAs to human endothelial cells. This increase in B lymphocyte proliferation can result in an increased supply of antibodies. Enhanced proliferation of T4 lymphocytes can improve communication of the immune system as a whole and provide overall immune support. Increased proliferation of T8 lymphocytes can also support immune resistance to pathogens.
Study results found that endothelial cells, in the presence of POAs, release the “endothelial lymphocyte-proliferation regulating factor" that decreases the proliferation of highly activated human B and T lymphoblasts in vitro (up to 90%). Inhibition of proliferation of highly activated B and T lymphoblasts plays a role in supporting a healthy immune system.
Conversely, TOAs inhibit the ability of POAs to enhance the release of this immune modulating factor. Therefore, TOAs reduce the proliferation of lymphocytes and the inhibition of proliferation of lymphoblasts dose-dependently (by up to 100%) when POAs and TOAs are mixed. More specifically, as little as 1% TOA content in an U. tomentosa product causes a 30% reduction of the inhibitory effects of POAs on lymphoblasts. Due to this antagonistic immunological effect, strictly controlled and lab tested harvesting and manufacturing procedures are required to ensure that only TOA-free U. tomentosa raw materials are used.
Other Effects of Saventaro
Research has indicated that POAs cause a dose-dependent, significant increase in proliferation of fibroblasts and fibrocytes (cells that are important in connective tissue functions).
Saventaro is safe for use by people with autoimmune diseases.
FAQ
What is Saventaro?
Saventaro is a special, patented form of Cat’s Claw (Uncaria tomentosa). Cat’s Claw is a vine deriving its name from hook-like thorns that resemble the claws of a cat. It grows in the tropical rainforests of South and Central America. Saventaro has been clinically studied to support healthy immune function.
How is Saventaro different than other Cat’s Claw products?
In nature, Cat’s Claw occurs in two distinct chemical compositions: one containing beneficial pentacyclic oxindole alkaloids (POAs), and another containing tetracyclic oxindole alkaloids (TOAs), which can have undesirable health effects. The highest concentration of helpful compounds is found in the roots of the vine. Saventaro is harvested from rootstock and uses a patented extraction method that guarantees it contains only POAs, which possess clinically demonstrated immune-modulating properties.
Can I take Saventaro daily?
Saventaro is safe for long-term immune support for most individuals.
GUARANTEE/ SHIPPING INFORMATION
Saventaro is shipped in a discrete, unmarked package. Orders are processed immediately and usually take about 3 to 5 working days to be received. We do ask that you try it for 2 to 3 weeks to feel the full effects. Any information received is used only for order processing and shipping purposes. Your information, such as e-mail address, will never be disclosed to a third party.
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Saventaro -
30 caps, (Enzymatic Therapy)
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