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Best 5 HTP 100mg -
Enhances Sense of Well-Being, 60 caps, (Doctor's Best)
5-HTP (5-hydroxy L-tryptophan) is a naturally occuring metabolite of the amino acid tryptophan which is converted in the brain to serotonin, a neurotransmitter substance found at the junctions between neurons. 5-HTP,extracted from the seeds of the Griffonia simplicifolia plant, helps maintain mental and emotional well-being and promotes healthy sleep.- Science-Based Nutrition
- Dietary Supplement
- Helps maintain mental and emotional well-being
5-HTP functions as the precursor for serotonin, a monoamine neurotransmitter found in the central nervous system (CNS) and some cells of the digestive tract. In the body, 5-HTP is formed by the addition of a hydroxyl group (–OH) to tryptophan, a reaction catalyzed by the enzyme tryptophan hydroxylase. This enzyme can be hindered by stress and conditions such as vitamin B6 deficiency, which is one reason B6 is included in this formula. Additionally, pyridoxal phosphate (vitamin B6) is necessary for 5-HTP to be converted to serotonin. Vitamin C participates in the conversion of tryptophan to 5-HTP and of tyrosine to norepinephrine, another important neurotransmitter.
Synthesis of serotonin in the brain requires an adequate supply of either tryptophan or 5-HTP as precursors in the CNS. The supply of tryptophan available for conversion to 5-HTP depends on a number of factors, including the nutritional status of the individual and the competition between tryptophan and other amino acids for transport across the blood-brain barrier. Whereas tryptophan may be sidetracked into the production of niacin or protein, 5-HTP readily crosses the blood-brain barrier and becomes available for serotonin synthesis. Therefore, supplementation with 5-HTP is a more direct route to serotonin production.
In contrast to tryptophan, orally consumed 5-HTP is readily absorbed by the mucosal cells of the gastrointestinal tract, with up to 70% then appearing in the bloodstream. The implications of possibly altering serotonin in this manner are significant: serotonergic neurons (nerve cells stimulated by serotonin) regulate sleep, appetite, nociception (the perception of pain), and aggressive behavior.
Enhances sense of well-being*
A synaptic serotonin deficit is hypothesized to be capable of a major adverse effect on mood. Supplementation with 5-HTP therefore is believed to balance mood via an increase in serotonin synthesis. This was researched extensively upon discovery that 5-HTP could be used to alter serotonin levels in rats. In a pilot study on humans, the subjects receiving 5-HTP showed a 35% increase on a mood rating scale, whereas the placebo group showed a 6% decrease.
A comprehensive review of seven open and seven controlled clinical studies found that oral consumption of 5-HTP improved mental and emotional status in 60 to 70 percent of subjects. The results varied from "modest" to "marked." Dosages ranged from 50 to 300 mg daily.
In a study of 134 recently bereaved men, mood was assessed using the Profile of Mood States (POMS) questionnaire. Men in this study who had adequate pyridoxine (vitamin B6) status had significantly better total mood disturbance (TMD) and confusion-bewilderment subscale scores. Additionally, pyridoxine deficiency was specifically related to a fatigued mood.
Promotes calming down and relaxing*
In a study of 32 healthy adults, half of the subjects were given 200 mg of 5-HTP, and the other half given placebo. All of the subjects were then given a stress-inducing substance (CCK-4) to provoke tension and elicit nervous irritability. In the female subjects who took the 5-HTP, there was a significant reduction in the rate and intensity of the negative cognitive reaction. This research built on previous studies where administration of 5-HTP produced a calming effect in subjects prone to nervous irritability.
Promotes satiety and supports healthy eating patterns*
May promote weight loss as part of a weight loss plan*
An exciting area of research recently regaining attention is the relationship between serotonin and appetite—and therefore its potential to aid in the maintenance of a healthy weight. While serotonin is renown for its function in the brain, 95% of serotonin is actually found in the gastrointestinal tract. Accordingly, serotonin is deeply involved in gut physiology, including visceral perception and weight maintenance. In research where 5-HTP was administered at higher doses, it was discovered that these high doses of 5-HTP produced weight loss in subjects, mainly through its influence on satiety and an altered appetite for specific macronutrients.
A study that orally administered either 5-HTP or placebo to 19 women for 5 weeks (without any dietary restrictions) resulted in significantly decreased food intake and weight loss in the women taking 5-HTP, compared to placebo. In a double-blind, randomized study, 20 subjects received either 5-HTP capsules or placebo for 6 weeks with dietary restrictions, and then for 6 weeks without dietary restrictions. During both periods (with or without dietary restrictions), the 5-HTP subjects experienced early satiety, a reduction in carbohydrate intake, and significant weight loss compared to placebo. In a subsequent double-blind, randomized study, 11 subjects received placebo and 9 subjects received 5-HTP capsules for 2 weeks. The 5-HTP group experienced weight loss through a significant decrease in carbohydrate and fat intake.
An animal study took experimental use of 5-HTP a step further by investigating food deprivation and also stress-induced eating. Although the 5-HTP was injected rather than orally administered in the rats, results clearly showed that administration of 5-HTP suppressed eating compared to placebo treatment in food-deprived rats and even more so in rats undergoing stress.
May improve quality of sleep*
Studies have shown that 5-HTP influences the quality of sleep by increasing REM (rapid eye movement) sleep. Administration of as little as 200 mg of 5-HTP in the evening prior to bedtime has been shown to increase the duration of REM sleep from 5 to 53% and decrease the amount of non-REM sleep.
Potent scavenger of free radicals*
Compounds such as vitamin E and flavonoids derive their free-radical quenching ability from their hydroxyl groups (–OH), which donate electrons to oxidants. 5-HTP is formed from tryptophan by the addition of an –OH group, which gives 5-HTP its antioxidant properties. This is in contrast to tryptophan, which is sensitive to oxidation. The effectiveness of 5-HTP in preventing lipid and protein oxidation is believed to contribute to liver cell integrity by countering membrane rigidity. A recent laboratory test demonstrated that 5-HTP is a more effective hydroxyl radical scavenger than even vitamin C.
SUGGESTED USAGE
As a dietary supplement, take 1 capsule two or three times daily, with or without a meal.
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Best 5 HTP 100mg -
Enhances Sense of Well-Being, 60 caps, (Doctor's Best)
| Supplement Facts | Serving Size: 1 capsule
Servings Per Container: 60 |  | | | %DV | | | 5-hydroxy L-tryptophan | 100 mg | † | | | | †Daily Value not yet established. | |
Other Ingredients: Rice powder, magnesium stearate, gelatin capsule.
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Best 5 HTP 100mg -
Enhances Sense of Well-Being, 60 caps, (Doctor's Best)
Editor's rating: 8 out of 10
User's rating:  100%  0%
USER'S OPINION
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Best 5 HTP 100mg -
Enhances Sense of Well-Being, 60 caps, (Doctor's Best)
FAQ
What do Doctor’s Best products NOT contain?
Milk, egg, wheat, corn, sugar, sweeteners, starch, salt, preservatives, or waxes. Because only natural products are used, taste, color and odor may vary.
If you’re allergic to shellfish, is it safe to take Glucosamine Sulfate?
People who are allergic to shellfish are allergic to the MEAT, not to the shells. The meat is not used to create the glucosamine, it is the ground-up shell.
Why does Doctor’s Best offer Lignisul MSM and not another brand?
Two major reasons for selecting Lignisul were and continue to be: - 1. It is made in the U.S. by using raw materials which are “grown” in the U.S. (pine trees);
- 2. the quality control used in all aspects of Lignisul’s production are the best in the industry.
The facts about Bioperine: Bioperine is a high purity compound extracted from black pepper and practically devoid of other compounds of black pepper which, like safarole, are contributing to the controversy of black pepper being carcinogenic. Piperine is not a carcinogen, and at a purity level of minimum 98% (Bioperine) it should not pose any concerns related to black pepper or black pepper extract.
Doctor’s Best Gelatin capsule information:
The gelatin used to make Doctor’s Best capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA developed these guidelines. Our gelatin is made only from cattle living in non-BSE countries. All Doctor’s Best capsules are in full compliance with the FDA’s guidance for our industry.
What about Veggie Caps?
Unlike ordinary animal-derived gelatin capsules, Veggie Caps are made from 100% pesticide-free plant material. If you’re a strict vegetarian or gelatin capsules present a problem for you, Veggie Caps are right for you.
What is HPLC?
HPLC stands for “High Performance Liquid Chromatography.” this is analytical lab testing method that is used to quantify the active ingredients in herbs. It is considered to be a very sensitive and accurate test. HPLC testing is recognized as a quality benchmark for herbal extracts.
How long should it take for a capsule to dissolve?
Approximately 30-45 minutes. For a 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes.
How does Celadrin compare with Best Glucosamine?
Celadrin is a complex of fatty acids that can affect the expression of certain cytokines that mediate occasional problems in the joints and other tissues. In this way, Celadrin actually complements the actions of glucosamine, which is a necessary building block for joint and cartilage tissue. Together, Celadrin and glucosamine provide an effective means to maintain the health and integrity of joint tissue.
Why is it important to supplement Calcium with Strontium Bone Maker?
Studies in postmenopausal women diagnosed with osteoporosis showed a strong benefit in women taking strontium plus calcium/Vitamin D versus woment taking calcium/Vitamin D plus a placebo. In one such study of 1,442 women, the strontium group had significant increases in bone mineral density and lumbar risk decreased by 41% compared to those given calcium/Vitamin D plus placebo.
NOTE: Should be taken at a different time of day, preferably 2 hours before or after any calcium supplement. It is also extremely important that adequate calcium and Vitamin D is taken, as strontium can compete with calcium uptake into bone.
What is an “ORAC Value”?
Short for “Oxygen Radical Absorbance Capacity,” ORAC is a widely method which measures the ability of foods and other substances to quench oxygen free radicals. Fruits such as cranberry, strawberry, plum, pink grapefruit, and tomato have very high ORAC values.
GUARANTEE/ SHIPPING INFORMATION
Best 5 HTP 100mg is shipped in a discrete, unmarked package. Orders are processed immediately and usually take about 3 to 5 working days to be received. We do ask that you try it for 2 to 3 weeks to feel the full effects. Any information received is used only for order processing and shippig purposes. Your information, such as e-mail address, will never be disclosed to a third party.
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Best 5 HTP 100mg -
Enhances Sense of Well-Being, 60 caps, (Doctor's Best)
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